Bendamustine, sold under the brand name Treanda, Treakisym, Ribomustin, Levact, Bendeka, others.
Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
BENDAMUSTINE INDICATIONS:
Bendamustine is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Bendamustine is used for:
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